ASP .NET 4.5.2 is the version packaged with CAM and that it was validated against.
Unless you have a pressing need to upgrade to 4.6 we would recommend you stay with that version for now. This applies to the STS server only, the proxy server does not rely on .NET. CAM has not been validated against 4.6.1."
Update: CAM 220.127.116.1183 has been tested with .net 4.6.1 and no issues were found.
.NET 4.7 has not been tested.