The following steps could help resolve the issue of the Defender Management Web Portal not generating reports. If the steps below do not resolve the issue call Quest Support for further troubleshooting.
Restart the defender service
Restart the ISS manager web service wait 10 seconds then start again
Re-enter the credentials for the DefenderPortal service account.
Confirm the the Defender Admin/Service account credentials for testing purposes.
Verified account in AD. It is Domain Admin, Enterprise Admin etc.
Check the "User service account for all actions" checkbox and verified that account had local admin permission (via Domain Admins and added account directly)
On each machine running a Defender Security Server, set up a network share for the Defender Security Server log directory. This will normally be located at C:\Program Files\Quest Software\Defender\DSS Active Directory Edition\Logs (or C:\Program Files (x86)\Quest Software\Defender\DSS Active Directory Edition\Logs on x64 platforms). The share should give read access to those users who are authorized to view the reports
There could be a problem with accessing the Temp folder (C:\Windows\Temp) or creating temp files in Temp folder during the report generation. This is may either be due to Temp folder not existing, or not having the appropriate permissions on Temp folder. Check that the Temp folder exists and that management portal service account has full permissions over the folder on the machine where the Defender Management Portal is installed. If any .tmp files already exist in the Temp folder then delete all the files and rerun the report to reproduce the issue.