SOLUTION 1
Enable .NET 3.5 components on the server running Quest Knowledge Portal.
Windows Server 2008 R2
Windows Server 2012
SOLUTION 2
Reinstall ASP.NET (2.9.50727), for example:
%windir%\Microsoft.NET\Framework64\v2.0.50727\aspnet_regiis.exe -i
SOLUTION 3
Revert handler mappings to parent.
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