No, Defender cannot limit access by MAC Address, computer/host name, or DNS name.
Defender provides RADIUS authentication and can limit access by AD group membership or IP address.
Instructions on how to limit access by AD group membership and IP address by using Access Nodes can be found in the Defender Administrator's Guide, Chapter 2: Managing Defender objects in Active Directory.
The guide can be downloaded from the Technical Documentation section of the Defender Support portal.
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